FGFR3 mutations can be found in different epithelial tumors and hamartomas
The fibroblast growth factor receptor 3 (FGFR3) is a member of the receptor tyrosine (FGFR1–4) involved in signal transduction regulating cell growth, differentiation, migration, wound healing and angiogenesis, depending on target cell type and developmental stage. Activating FGFR3 germline mutations cause skeletal dysplasia and craniosynostosis syndromes. Somatic FGFR3 mutations have been identified in several cancer entities such as urothelial carcinoma and multiple myeloma. Recently, somatic FGFR3 mutations have been identified in benign acanthotic skin tumors such as seborrheic keratoses and epidermal nevi that share many histological features. (more…)
